Pharmacologic Effect Ambien is a hypnotic drug belonging to the imidazopyridine group, and is a selective agonist of the subclass of omega1-benzodiazepine receptors. It has a sedative effect, while when used in normal doses, it does not have an anxiolytic, central muscle relaxant and anticonvulsant effect. Excites benzodiazepine receptors (omega) in the alpha subunit of GABA receptor complexes localized in the region of the IV plate of the sensory-motor zones of the cortex, reticular sections of the substantia nigra, visual tubercles of the ventral thalamic complex, bridge, pale ball, etc. Interaction with omega receptors leads to the discovery of neuronal isoform channels for chlorine ions. Ambien Fast Shipping USA as it Shortens the time of falling asleep, reduces the number of night awakenings, increases the total duration of sleep and improves its quality. Extends the II stage of sleep and the stage of deep sleep (III and IV). Does not cause drowsiness during the day. Indications of The Drug Ambien sleep disturbances: difficulty falling asleep, early and night awakenings. Dosage Regimen Inside (immediately before bedtime) in a single dose of 10 mg. In elderly or debilitated patients, in case of impaired liver function, treatment begins with a dose of 5 mg. If necessary (insufficient clinical effect) and good tolerability of the drug, the dose can be increased to 10 mg. The maximum daily dose is 10 mg. The course of treatment should not exceed 4 weeks. With transient insomnia, the recommended course of treatment is 2-5 days, with situational - 2-3 weeks, buy ambien online legally from the USA drug store. Very short treatment periods do not require gradual discontinuation of the drug. In the case of prolonged use of the drug to reduce the possibility of developing rebound insomnia, the abolition of Ambien should be carried out gradually (first, reducing the daily dose and then discontinuing the drug). Side Effect Ambien is usually well tolerated. The Frequency of Adverse Reactions: very often - more than 10%, often more than 1% and less than 10%, infrequently - more than 0.1% and less than 1%), rarely - more than 0.01% and less than 0.1%, very rarely - less than 0.01% ( including individual cases), the frequency is unknown (based on the available data, the establishment of the frequency of occurrence is impossible). From the nervous system:often - drowsiness, a feeling of intoxication, headache, dizziness, increased insomnia, anterograde amnesia (the effects of amnesia can be associated with behavioral reactions), the risk of which increases in proportion to the dose, hallucinations, agitation, nightmares; infrequently - confusion, irritability; the frequency is unknown - impaired consciousness, dysphoria, aggressiveness, visual and auditory hallucinations, increased irritability, behavioral reactions, somnambulism, drug dependence (can develop even with therapeutic doses), with drug withdrawal - withdrawal syndrome or rebound insomnia, decreased libido, impaired gait , ataxia, falls (mainly in elderly patients), addiction to the drug (decrease in sedative and hypnotic effects when used for several weeks). Most side effects from the psyche are paradoxical reactions. From the digestive system: often - diarrhea, nausea, vomiting, abdominal pain; frequency unknown - increased activity of liver enzymes. From the musculoskeletal system: the frequency is unknown - muscle weakness. From the skin: the frequency is unknown - rash, itching, urticaria, hyperhidrosis. Allergic reactions: frequency unknown - angioedema. Others: often - a feeling of tiredness; infrequently - diplopia. With caution: severe myasthenia gravis, respiratory failure, mild to moderate liver failure, depression, alcoholism, drug addiction and other types of dependence. Pregnancy and lactation The drug is contraindicated in pregnancy and lactation. Use for impaired liver function Contraindicated in acute or chronic liver failure. With caution: hepatic insufficiency of mild to moderate severity. In case of impaired liver function, treatment begins with a dose of 5 mg. If necessary (insufficient clinical effect) and good tolerability of the drug, the dose can be increased to 10 mg. The maximum daily dose is 10 mg. The course of treatment should not exceed 4 weeks. With transient insomnia, the recommended course of treatment is 2-5 days, with situational - 2-3 weeks. Use in children Contraindicated in children under 18 years of age. Use in Elderly Patients In elderly patients, treatment begins with a dose of 5 mg. If necessary (insufficient clinical effect) and good tolerability of the drug, the dose can be increased to 10 mg. The maximum daily dose is 10 mg. The course of treatment should not exceed 4 weeks. With transient insomnia, the recommended course of treatment is 2-5 days, with situational - 2-3 weeks. so you can order Ambien online from the USA portal. In elderly patients, mental and behavioral (including paradoxical) reactions may occur. If such reactions occur, Ambien should be discontinued In elderly patients or with impaired liver function, a significant increase in T 1/2 of Ambien is possible , which can lead to cumulation of the drug when it is taken again. When using Ambien in the elderly, care must be taken, due to the risk of developing pronounced sedative and / or muscle relaxant effects. Special Instructions Persistence of insomnia for 7-14 days of treatment indicates the presence of primary mental disorders and / or disorders of the nervous system. Therefore, to identify these disorders, it is necessary to regularly reassess the patient's condition. To reduce the risk of developing anterograde amnesia, patients should have conditions for continuous 7-8 hours of sleep. When Ambien is used, mental and behavioral (including paradoxical) reactions can occur (the risk of development is higher in elderly patients). If such reactions occur, the intake of Ambien should be discontinued. After a course of treatment for several weeks, a slight decrease in the sedative and hypnotic effects of Ambien is possible.
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